PrIMe—Process Informatics Model—is a new approach for developing predictive models of chemical reaction systems that is based on the scientific collaboratory paradigm and takes full advantage of existing and developing cyber infrastructure. The primary goals of PrIMe are collecting and storing data, validating the data and quantifying uncertainties, and assembling the data into predictive models with quantified uncertainties to meet specific user requirements. The principal components of PrIMe include: a data Depository, which is a repository of data provided by the community, a data Library for storage of evaluated data, and a set of computer-based tools to process data and to assemble data into predictive models. Two guiding principles of PrIMe are: open membership—a qualified individual or industrial organization can register to participate in the project; and open source—all submitted data, tools and models will be in the public domain.